Epstein-Barr Virus (EBV) Antibody Profile is a comprehensive test that measures multiple antibodies to determine EBV infection status and stage. This test detects IgM and IgG antibodies against viral capsid antigen (VCA) and IgG antibodies against Epstein-Barr nuclear antigen (EBNA). IgM VCA antibodies indicate recent or active infection, while IgG VCA antibodies suggest past infection. EBNA antibodies typically appear 2-4 months after infection and persist for life. This profile helps distinguish between acute, recent, and past EBV infections, and is particularly valuable for evaluating patients with suspected infectious mononucleosis, unexplained fatigue, or other symptoms that may be related to EBV infection. The test also helps determine susceptibility to future EBV infection in immunocompromised patients.