Isocyanates Profile is a specialized occupational allergy test that measures immunoglobulin E (IgE) antibodies to three common industrial isocyanates: toluene diisocyanate (TDI), methylene diphenyl diisocyanate (MDI), and hexamethylene diisocyanate (HDI). These chemicals are widely used in manufacturing processes including plastics, polyurethane foams, paints, adhesives, and automotive materials. Exposure to isocyanates can cause occupational asthma, chemical bronchitis, hypersensitive pneumonitis, and contact dermatitis. This test is particularly valuable for evaluating workers with suspected occupational respiratory conditions, monitoring workplace exposure levels, and diagnosing work-related allergic reactions. The profile helps distinguish between isocyanate-specific allergies and other respiratory conditions, guiding workplace safety measures and medical management.