Cortisol, Serum LC/MS is a highly accurate test that measures cortisol levels using liquid chromatography-mass spectrometry technology. This advanced methodology provides superior specificity and sensitivity compared to traditional immunoassays, making it the gold standard for cortisol measurement. Cortisol is a steroid hormone produced by the adrenal glands that plays crucial roles in metabolism, immune function, blood pressure regulation, and stress response. This test is particularly valuable for evaluating patients with suspected adrenal disorders, monitoring cortisol replacement therapy, and assessing the hypothalamic-pituitary-adrenal axis. The LC/MS method helps avoid interference from other steroids and provides more reliable results in patients with complex medical conditions.